What is DSIP?
DSIP, delta sleep-inducing peptide, is a nine-amino-acid peptide isolated in 1977 from rabbits kept asleep by brain stimulation. Decades later its gene, precursor and receptor are still unknown, and its effects on sleep have been inconsistent. Here is its structure, discovery and what the research does and does not show.
DSIP in one table.
| Sequence | WAGGDASGE (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) |
|---|---|
| Length | 9 amino acids, a nonapeptide |
| Formula | C35H48N10O15 |
| Molecular weight | 848.8 g/mol (monoisotopic 848.3301) |
| CAS number | 62568-57-4 |
| PubChem CID | 68816 |
| Other name | Emideltide (INN) |
| Status | Research compound |
Formula and masses from Helion's peptide molecular weight calculator, matching PubChem.
From sleeping rabbits.
In 1977 Guido Schoenenberger and Marcel Monnier reported a peptide from the cerebral venous blood of rabbits kept in slow-wave sleep by electrical stimulation of the thalamus, which seemed to induce delta-wave sleep in recipient animals. They sequenced it as the nonapeptide WAGGDASGE and named it for that effect.
No gene, no receptor.
Despite decades of work, no gene, precursor protein or receptor for DSIP has been identified, and a 2006 review titled it a still unresolved riddle. A 77-residue protein from porcine brain that a DSIP antiserum recognizes turned out to have an unrelated sequence. A 2011 paper proposed histone demethylases of the JMJD1B type, which carry a similar motif, as putative precursors, but that remains unconfirmed.
Inconsistent sleep effects.
Later studies did not consistently reproduce the original sleep effect: a 1980 rat study, for example, found no significant increase in sleep. Research broadened to EEG, neurotransmitter, circadian and locomotor activity, hormone and stress models, reviewed in 1984, but the sleep-factor hypothesis that gave DSIP its name remains weak.
Not currently supplied.
Helion does not currently supply DSIP. The research library covers the compounds it does supply, each with its own reference page and lab report.
Specs and storage by compound.
Questions (7)
What is DSIP?
Delta sleep-inducing peptide, a nine-amino-acid peptide (WAGGDASGE) isolated in 1977 from rabbits in stimulated sleep.
What does DSIP stand for?
Delta sleep-inducing peptide, named for the delta-wave sleep it seemed to induce in the original experiments.
What is the DSIP sequence?
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.
Does DSIP have a receptor?
None has been identified, and neither has its gene or precursor protein.
Does DSIP cause sleep?
The original finding has not been reproduced consistently; a 1980 rat study found no significant increase in sleep.
What is the molecular weight of DSIP?
848.8 g/mol (C35H48N10O15).
Does Helion sell DSIP?
Not currently.
Published studies (7)
- Characterization of a delta-electroencephalogram (-sleep)-inducing peptide
- Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP)
- Delta sleep-inducing peptide (DSIP): a still unresolved riddle
- A novel 77-residue peptide from porcine brain contains a leucine-zipper motif and is recognized by an antiserum to delta-sleep-inducing peptide
- JmjC-domain-containing histone demethylases of the JMJD1B type as putative precursors of endogenous DSIP
- Effect of delta sleep inducing peptide (DSIP) and arginine vasotocin (AVT) on sleep and motor activity in the rat
- Delta-sleep-inducing peptide (DSIP): a review
Citations from PubMed for reference. They describe the compound in the literature, not any Helion lot, and nothing here is guidance on use.