What is KLOW peptide?
KLOW is a market name for a four-peptide research blend: GHK-Cu, BPC-157, TB-500 and KPV, most often sold as an 80 mg vial. It is the GLOW blend with one addition, KPV. Here is what is in it, what each component is, and how to check what a KLOW vial actually holds.
Four peptides in one vial.
| Component | Usual amount | What it is | Mass (g/mol) |
|---|---|---|---|
| GHK-Cu | 50 mg | Copper(II) complex of the naturally occurring tripeptide Gly-His-Lys | 340.4 (GHK, without copper) |
| BPC-157 | 10 mg | A 15-amino-acid sequence first described from a gastric protein | 1419.5 |
| TB-500 | 10 mg | The acetylated 17-23 fragment of thymosin beta-4, Ac-LKKTETQ | 889.0 |
| KPV | 10 mg | Lys-Pro-Val, the C-terminal tripeptide of alpha-MSH | 342.4 |
Amounts as sellers commonly list them for an 80 mg vial, often labeled KLOW 80. The name is not a standard, so for any specific vial the label and the lot's lab report are the record.
What KLOW adds.
KPV is the tripeptide Lys-Pro-Val, the last three residues of alpha-melanocyte-stimulating hormone (alpha-MSH). Work on alpha-MSH traced part of its activity on immune cells to this C-terminal fragment, which also binds the melanocortin-1 receptor. A 2008 study showed that cells take KPV up through PepT1, a transporter for di- and tripeptides, and that it reduced colitis in two mouse models. A dimer built from two KPV units, (CKPV)2, has been studied separately in cell and rat models of endotoxin responses. What is KPV peptide? covers it in full.
At 342.4 g/mol, KPV weighs almost exactly what the GHK in GHK-Cu does, about 2 apart, a gap mass spectrometry resolves easily.
The other three components.
The rest of KLOW is the GLOW blend. GHK-Cu is the copper(II) complex of a naturally occurring tripeptide that binds copper through its N-terminal amine, the first amide nitrogen and histidine's imidazole; it makes up most of the vial by weight. BPC-157 and TB-500 are the same pair sold together as Wolverine; BPC-157 vs TB-500 covers how they differ. What is GLOW peptide? covers the three-peptide version, and GLOW vs KLOW compares the two.
Four masses, one report.
A blend's lab report has to address every component: an identity result that confirms GHK-Cu says nothing about the other three. Mass spectrometry can confirm all four in one sample by their masses; check them in the calculator: GHK, BPC-157, TB-500, KPV. For a mixture, ask whether purity is reported per component or for the blend as a whole. How peptides are tested and purity vs net peptide content explain each number.
The components Helion carries.
Helion does not currently list KLOW, or KPV on its own. It supplies three of KLOW's four components in two products: GHK-Cu 50mg (CU50), lot CU501 at 99.92% HPLC purity, and Wolverine (BB10), 5mg BPC-157 + 5mg TB-500 per vial, whose current lot report is in progress. Both are for laboratory research use only.
Specs and storage by compound.
Questions (6)
What is KLOW peptide?
A market name for a research blend of four peptides: GHK-Cu, BPC-157, TB-500 and KPV, most often sold as an 80 mg vial.
What is in KLOW?
Commonly 50 mg GHK-Cu and 10 mg each of BPC-157, TB-500 and KPV. Contents vary by seller, so check the label and the lot's lab report.
What is KLOW 80?
An 80 mg vial of the KLOW blend, commonly 50 mg GHK-Cu plus 10 mg each of BPC-157, TB-500 and KPV.
What is the difference between KLOW and GLOW?
KLOW adds a fourth peptide, KPV, to GLOW's GHK-Cu, BPC-157 and TB-500.
What is KPV in KLOW?
Lys-Pro-Val, the C-terminal tripeptide of alpha-MSH, studied in cell and mouse models of inflammation.
Does Helion sell KLOW?
Not currently. Helion supplies GHK-Cu 50mg and Wolverine (BPC-157 + TB-500) separately, for laboratory research use only.
Published studies (5)
- PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
- Inhibitory effects of the peptide (CKPV)2 on endotoxin-induced host reactions
- New insights into the functions of alpha-MSH and related peptides in the immune system
- X-ray and solution structures of Cu(II) GHK and Cu(II) DAHK complexes: influence on their redox properties
- Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential
Citations from PubMed for reference. They describe the compound in the literature, not any Helion lot, and nothing here is guidance on use.